MSF-OCA has been addressing a highly relevant issue, TB and DR-TB in Uzbekistan. A steady decrease of the notification and the mortality rates has been indicating a good outcome of the TB DOTS programme. MSF is highly appreciated by the MOH of Uzbekistan as one of the main partners in TB control and the first one who started the diagnosis and treatment of DR-TB. The current model of comprehensive TB care was estimated as the most appropriate approach for this low-income country with high TB/MDR-TB burden. It could be successfully expanded to elsewhere in the region.